Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.49	11.65	-127.02	5	13	-2	216	550.62	16	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	1.49	12.1	-124.27	6	13	-1	217	551.628	16	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
DYR-1-E	Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic	Eukaryotes	18	0.27	Binding ≤ 10μM
DYR-1-B	Dihydrofolate Reductase (cluster #1 Of 1), Bacterial	Bacteria	12	0.28	Functional ≤ 10μM
Z50266-1-O	Enterococcus Faecium (cluster #1 Of 1), Other	Other	410	0.22	Functional ≤ 10μM
Z50362-1-O	Lactobacillus Casei (cluster #1 Of 1), Other	Other	17	0.27	Functional ≤ 10μM
Z80193-2-O	L1210 (Lymphocytic Leukemia Cells) (cluster #2 Of 12), Other	Other	217	0.23	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
DYR_MOUSE	P00375	Dihydrofolate Reductase, Mouse	17.5	0.27	Binding ≤ 1μM
DYR_MOUSE	P00375	Dihydrofolate Reductase, Mouse	17.5	0.27	Binding ≤ 10μM
DYR_LACCA	P00381	Dihydrofolate Reductase, Lacca	12	0.28	Functional ≤ 10μM
Z50266	Z50266	Enterococcus Faecium	410	0.22	Functional ≤ 10μM
Z80193	Z80193	L1210 (Lymphocytic Leukemia Cells)	217	0.23	Functional ≤ 10μM
Z50362	Z50362	Lactobacillus Casei	17	0.27	Functional ≤ 10μM

Description	Species
E2F mediated regulation of DNA replication	Mus musculus (DYR_MOUSE)
G1/S-Specific Transcription	Mus musculus (DYR_MOUSE)
Metabolism of folate and pterines	Mus musculus (DYR_MOUSE)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Mus musculus (DYR_MOUSE)