Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.02	0.19	-57.31	10	12	1	207	583.71	16	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.02	-0.11	-20.05	9	12	0	206	582.702	16	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	9	0.27	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	6	0.27	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	46	0.24	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	29	0.25	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	4.06	0.28	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	10.1	0.27	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	4.06	0.28	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	10.1	0.27	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	45.6	0.24	Functional ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	28.7	0.25	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN) Rattus norvegicus (OPRD_RAT) Mus musculus (OPRD_MOUSE)
G-protein activation	Homo sapiens (OPRM_HUMAN) Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT) Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Rattus norvegicus (OPRD_RAT) Homo sapiens (OPRM_HUMAN) Mus musculus (OPRD_MOUSE)