Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.08	1.72	-57.74	10	12	1	207	611.764	18	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.08	1.39	-19.68	9	12	0	206	610.756	18	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	10	0.25	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	4	0.27	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	25	0.24	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	25	0.24	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	4.35	0.27	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	2.27	0.28	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	4.35	0.27	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	2.27	0.28	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	25.2	0.24	Functional ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	24.6	0.24	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN) Rattus norvegicus (OPRD_RAT) Mus musculus (OPRD_MOUSE)
G-protein activation	Homo sapiens (OPRM_HUMAN) Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT) Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN) Mus musculus (OPRD_MOUSE) Rattus norvegicus (OPRD_RAT)