Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.64	2.5	-107.62	11	11	2	200	622.811	15	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.64	1.93	-25.25	9	11	0	196	620.795	15	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.64	2.18	-62.18	10	11	1	198	621.803	15	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.64	2.25	-63.71	10	11	1	198	621.803	15	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	32	0.23	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.24	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.27	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	31.9	0.23	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	0.1	0.31	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	31.9	0.23	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	0.1	0.31	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	25.8	0.24	Functional ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	1.79	0.27	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Rattus norvegicus (OPRD_RAT) Mus musculus (OPRD_MOUSE)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Mus musculus (OPRD_MOUSE) Rattus norvegicus (OPRD_RAT)