| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 25th, 2009 | 18 | Yes |
Popular Name: (2R,6S,8S)-2-(carboxymethyl)-9-azaspiro[5.5]undecane-8-carboxylic (2R,6S,8S)-2-(carboxymethyl)-9-a…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.40 | 6.93 | -70.03 | 2 | 5 | -1 | 97 | 254.306 | 3 | ↓ |
| Lo Low (pH 4.5-6) | -0.40 | 4.94 | -37.46 | 3 | 5 | 0 | 94 | 255.314 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| A2AIR5-1-E | Glutamate [NMDA] Receptor Subunit 3A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMD3B-2-E | Glutamate [NMDA] Receptor Subunit 3B (cluster #2 Of 2), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE1-1-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE2-1-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE3-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE4-1-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| NMDZ1-1-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 7800 | 0.40 | Functional ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 4298 | 0.42 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z104302 | Z104302 | Glutamate NMDA Receptor | 4298 | 0.42 | Binding ≤ 10μM |
| NMDZ1_MOUSE | P35438 | Glutamate (NMDA) Receptor Subunit Zeta 1, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| A2AIR5_MOUSE | A2AIR5 | Glutamate [NMDA] Receptor Subunit 3A, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| NMD3B_MOUSE | Q91ZU9 | Glutamate [NMDA] Receptor Subunit 3B, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE1_MOUSE | P35436 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE2_MOUSE | Q01097 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE3_MOUSE | Q01098 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| NMDE4_MOUSE | Q03391 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Mouse | 7800 | 0.40 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| EPHB-mediated forward signaling | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
