| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 26th, 2009 | 22 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -4.81 | -16.28 | -42.89 | 11 | 11 | 1 | 208 | 328.294 | 2 | ↓ |
| Mid Mid (pH 6-8) | -4.81 | -16.6 | -14.26 | 10 | 11 | 0 | 206 | 327.286 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLCB3-1-E | Phospholipase C-beta-3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.36 | Binding ≤ 10μM |
| PLCG2-1-E | Phospholipase C-gamma-2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLCB3_HUMAN | Q01970 | Phospholipase C-beta-3, Human | 2000 | 0.36 | Binding ≤ 10μM |
| PLCG2_HUMAN | P16885 | Phospholipase C-gamma-2, Human | 2000 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Acetylcholine regulates insulin secretion | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| Ca2+ pathway | |
| DAP12 signaling | |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| G alpha (q) signalling events | |
| G beta:gamma signalling through PLC beta | |
| GPVI-mediated activation cascade | |
| PLC beta mediated events | |
| Presynaptic function of Kainate receptors | |
| Role of phospholipids in phagocytosis | |
| Synthesis of IP3 and IP4 in the cytosol | |
| Toll Like Receptor 4 (TLR4) Cascade |
