| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 26th, 2009 | 29 | Yes |
Popular Name: 2-(4-butylanilino)-9-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-ol 2-(4-butylanilino)-9-[(2R,4S,5S)…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.31 | 5.5 | -18.8 | 4 | 9 | 0 | 125 | 399.451 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA-1-E | DNA Polymerase Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2300 | 0.27 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 2300 | 0.27 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the pre-replicative complex | |
| DNA replication initiation | |
| E2F mediated regulation of DNA replication | |
| G1/S-Specific Transcription | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Leading Strand Synthesis | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of the Flap Intermediate | |
| Telomere C-strand synthesis initiation |
