| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 26th, 2005 | 24 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.85 | -1.19 | -5.53 | 4 | 4 | 0 | 81 | 338.488 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| UniProt Database Links | ACS_PLEBE; CDKA1_ARATH; CNDH2_ARATH; DPOLQ_HUMAN; FACD2_HUMAN; GENL2_ORYSJ; UHRF1_MOUSE | ChEBI |
| PUBCHEM_PATENT_ID | EP0112603A1; EP0112603B2; EP0192279A1; EP0315782A2; EP0315782B1; EP0337441A2; EP0370171A2; EP0370171B1; EP0430511A1; EP0456188B1; EP0475160B1; EP0475719A3; EP0504289A1; EP0504289B1; EP0575546A1; EP0604560A1; EP0606210A1; EP0606210B1; EP0610420A1; EP061042 | IBM Patent Data |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA-2-E | DNA Polymerase Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3000 | 0.32 | Binding ≤ 10μM |
| DPOL-2-V | Human Herpesvirus 6 DNA Polymerase (cluster #2 Of 4), Viral | Viruses | 400 | 0.37 | Binding ≤ 10μM |
| Z50602-2-O | Human Herpesvirus 1 (cluster #2 Of 2), Other | Other | 438 | 0.37 | Binding ≤ 10μM |
| Z50602-3-O | Human Herpesvirus 1 (cluster #3 Of 5), Other | Other | 590 | 0.36 | Functional ≤ 10μM |
| Z80583-2-O | Vero (Kidney Cells) (cluster #2 Of 3), Other | Other | 580 | 0.36 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOL_VZVD | P09252 | DNA Polymerase, Vzvd | 600 | 0.36 | Binding ≤ 1μM |
| DPOL_HHV1K | P04292 | DNA Polymerase Catalytic Subunit, Hhv1k | 438 | 0.37 | Binding ≤ 1μM |
| Z50602 | Z50602 | Human Herpesvirus 1 | 438 | 0.37 | Binding ≤ 1μM |
| DPOL_HHV11 | P04293 | Human Herpesvirus 1 DNA Polymerase, Hhv11 | 500 | 0.37 | Binding ≤ 1μM |
| DPOL_HCMVA | P08546 | Human Herpesvirus 5 DNA Polymerase, Hcmva | 400 | 0.37 | Binding ≤ 1μM |
| DPOL_HHV6U | P28857 | Human Herpesvirus 6 DNA Polymerase, Hhv6u | 400 | 0.37 | Binding ≤ 1μM |
| DPOL_VZVD | P09252 | DNA Polymerase, Vzvd | 2600 | 0.33 | Binding ≤ 10μM |
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 2000 | 0.33 | Binding ≤ 10μM |
| DPOL_HHV1K | P04292 | DNA Polymerase Catalytic Subunit, Hhv1k | 438 | 0.37 | Binding ≤ 10μM |
| Z50602 | Z50602 | Human Herpesvirus 1 | 438 | 0.37 | Binding ≤ 10μM |
| DPOL_HHV11 | P04293 | Human Herpesvirus 1 DNA Polymerase, Hhv11 | 500 | 0.37 | Binding ≤ 10μM |
| DPOL_HCMVA | P08546 | Human Herpesvirus 5 DNA Polymerase, Hcmva | 400 | 0.37 | Binding ≤ 10μM |
| DPOL_HHV6U | P28857 | Human Herpesvirus 6 DNA Polymerase, Hhv6u | 400 | 0.37 | Binding ≤ 10μM |
| Z50602 | Z50602 | Human Herpesvirus 1 | 590 | 0.36 | Functional ≤ 10μM |
| Z80583 | Z80583 | Vero (Kidney Cells) | 580 | 0.36 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the pre-replicative complex | |
| DNA replication initiation | |
| E2F mediated regulation of DNA replication | |
| G1/S-Specific Transcription | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Leading Strand Synthesis | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of the Flap Intermediate | |
| Telomere C-strand synthesis initiation |
