| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 5th, 2010 | 30 | No |
Popular Name: 1-[4-[2-(4-piperidyl)ethyl]-1-piperidyl]pentadecan-1-one 1-[4-[2-(4-piperidyl)ethyl]-1-pi…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 8.44 | 16.66 | -43.98 | 2 | 3 | 1 | 37 | 421.734 | 16 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GNAI1-1-E | Guanine Nucleotide-binding Protein G(i), Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6600 | 0.24 | Binding ≤ 10μM |
| GNAI3-1-E | Guanine Nucleotide-binding Protein G(k), Alpha-3 Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6300 | 0.24 | Binding ≤ 10μM |
| GNAO-1-E | Guanine Nucleotide-binding Protein G(o), Alpha Subunit 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6100 | 0.24 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GNAI1_HUMAN | P63096 | Guanine Nucleotide-binding Protein G(i), Alpha-1 Subunit, Human | 6600 | 0.24 | Binding ≤ 10μM |
| GNAI3_HUMAN | P08754 | Guanine Nucleotide-binding Protein G(k), Alpha-3 Subunit, Human | 6300 | 0.24 | Binding ≤ 10μM |
| GNAO_HUMAN | P09471 | Guanine Nucleotide-binding Protein G(o), Alpha Subunit 1, Human | 6100 | 0.24 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Adenylate cyclase inhibitory pathway | |
| ADP signalling through P2Y purinoceptor 12 | |
| Adrenaline,noradrenaline inhibits insulin secretion | |
| Ca2+ pathway | |
| G alpha (i) signalling events | |
| G alpha (s) signalling events | |
| G alpha (z) signalling events | |
| G-protein activation | |
| PLC beta mediated events | |
| Regulation of insulin secretion |
