| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 12th, 2010 | 23 | Yes |
Popular Name: 6-[1-methyl-3-(4-pyridyl)pyrazol-4-yl]naphthalen-2-ol 6-[1-methyl-3-(4-pyridyl)pyrazol…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.17 | 6.87 | -10.7 | 1 | 4 | 0 | 51 | 301.349 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 3.17 | 7.33 | -39 | 2 | 4 | 1 | 52 | 302.357 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| BRAF-1-E | Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic | Eukaryotes | 77 | 0.43 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| BRAF_HUMAN | P15056 | Serine/threonine-protein Kinase B-raf, Human | 77 | 0.43 | Binding ≤ 1μM |
| BRAF_HUMAN | P15056 | Serine/threonine-protein Kinase B-raf, Human | 77 | 0.43 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| ARMS-mediated activation | |
| CREB phosphorylation through the activation of Ras | |
| Frs2-mediated activation | |
| Signalling to p38 via RIT and RIN | |
| Spry regulation of FGF signaling |
