| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 3rd, 2005 | 28 | No |
Popular Name: Pyrogallol Red Pyrogallol Red
Find On: PubMed — Wikipedia — Google
CAS Number: 32638-88-3
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.10 | 0.1 | -60.91 | 3 | 8 | -1 | 148 | 399.356 | 2 | ↓ |
| Hi High (pH 8-9.5) | 0.10 | 0.83 | -107.44 | 2 | 8 | -2 | 151 | 398.348 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NFKB1-1-E | Nuclear Factor NF-kappa-B P105 Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 10000 | 0.25 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NFKB1_HUMAN | P19838 | Nuclear Factor NF-kappa-B P105 Subunit, Human | 10000 | 0.25 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of NF-kappaB in B cells | |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | |
| Downstream TCR signaling | |
| FCERI mediated NF-kB activation | |
| Interleukin-1 processing | |
| Interleukin-1 signaling | |
| NF-kB is activated and signals survival | |
| Regulated proteolysis of p75NTR | |
| RIP-mediated NFkB activation via ZBP1 | |
| Senescence-Associated Secretory Phenotype (SASP) | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | |
| TRAF6 mediated NF-kB activation | |
| Transcriptional regulation of white adipocyte differentiation |
