UCSF

ZINC03869280

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 4th, 2005 11 No

Popular Name: O-PHOSPHO-L-SERINE O-PHOSPHO-L-SERINE

Find On: PubMed — Wikipedia — Google

CAS Numbers: 17885-08-4 , 17885-08-4; 407-41-0 , 407-41-0 , 58823-92-0 , 7331-08-0

Other Names:

(+)-L-serine dihydrogen phosphate (ester); (2S)-2-amino-3-(phosphonooxy)propanoic acid; O-phosphoserine; phosphoserine

(+)-L-Serine dihydrogen phosphate (ester); (S)-2-amino-3-hydroxypropanoic acid 3-phosphate; 3-Phosphoserine; Dexfosfoserine; Dexfosfoserine [INN]; Fosforina; L-2-Amino-3-hydroxypropanoic acid 3-phosphate; L-O-Phosphoserine; L-SOP; L-Serine O-phosphate; O-

(+)-L-Serine dihydrogen phosphate (ester); Dexfosfoserine [INN]; EINECS 206-986-0; Fosforina; LS-184497; O-Phosphoserine; Phosphatidalserine; Phosphoserine

(2S)-2-ammonio-3-(phosphonatooxy)propanoate; O-phospho-L-serine

17885-08-4; 3-P-serine; 3-phospho-L-serine; 3-phospho-serine; 3-phosphoserine; 407-41-0; O-phospho-L-serine; P-ser; P-serine; phosphorylserine; phosphoserine; serine phosphate; serine-3-p; serine-3-phosphate; seryl phosphate

2-ammonio-3-(phosphonatooxy)propanoate; O-phosphonatooxyserine

3-O-Phosphoserine; Dexfosfoserine; Fosforina; L-3-Phosphoserine; L-O-Phosphoserine; L-O-Serine phosphate; L-Phosphoserine; L-Serine dihydrogen phosphate (ester); L-Serine phosphate; L-Serinephosphorate; L-Serinephosphoric acid; L-Seryl phosphate

3-O-Phosphoserine;Dexfosfoserine;Fosforina;L-3-Phosphoserine;L-O-Phosphoserine;L-O-Serine phosphate;L-Phosphoserine;L-Serine dihydrogen phosphate (ester);L-Serine phosphate;L-Serinephosphorate;L-Serinephosphoric acid;L-Seryl phosphate

3-phospho-1-serine; 3-phospho-serine; 3-phosphoserine; DL-O-Phosphorylserine; DL-O-Phosphoserine; DL-O-Serine phosphate; DL-Serine dihydrogen phosphate; DL-Serine monophosphorate; DL-Serine monophosphoric acid; Energoserina; O-Phospho-DL-serine; O-phospho

3-Phosphoserine; 407-41-0; C01005; Dexfosfoserine; L-O-Phosphoserine; O-Phospho-L-serine

CHEBI:21966; CHEBI:7692; CHEBI:12718

DEXFOSFOSERINE

Dexfosfoserine (INN)

DL-O-Phosphoserine

Dl-o-phosphoserine, barium salt

GNF-PF-1028

L-Serine, dihydrogen phosphate (ester), compd. with N-(1-methylethyl)-2-propanamine (1:2); LS-145003; Phosphoserinate de bis diisopropylamine [French]

MFCD00021723

MFCD00065935

MFCD00070491

O-PHOSPHO-DL-SERINE

O-phosphonato-L-serine(2-)

O-phosphonatooxyserine(2-)

O-phosphonoserine

Phosphonoserine

Phosphoserine

QB-6965

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.29 -1.1 -142.53 3 7 -2 140 183.056 4 ↓
Lo Low (pH 4.5-6) -4.29 -2.27 -64.66 4 7 -1 137 184.064 4 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.99e+01 g/l DrugBank-experimental
UniProt Database Links 14331_ARATH; 14334_ARATH; 14335_ARATH; 14339_ARATH; 1433B_BOVIN; 1433B_CHICK; 1433B_HUMAN; 1433B_MACFA; 1433B_MOUSE; 1433B_PONAB; 1433B_RAT; 1433B_SHEEP; 1433B_XENTR; 1433E_BOVIN; 1433E_CHICK; 1433E_DROME; 1433E_HUMAN; 1433E_MOUSE; 1433E_RAT; 1433E_SHEEP ChEBI
Therapy Competitive NMDA glutamate receptor antagonist with close structural similarity to L-glutamate SMDC Pharmakon
UniProt Database Links CYAS_METAC; CYAS_METB6; CYAS_METBF; CYAS_METBU; CYAS_METHJ; CYAS_METLZ; CYAS_METMA; CYAS_METMJ; CYAS_METPE; CYAS_METPS; CYAS_METTP; CYAS_UNCMA; CYSM_MYCBO; CYSM_MYCTU; CYSO_AERPE; PLPP_BOVIN; PLPP_HUMAN; PLPP_MOUSE; PLPP_RAT; PSPA_HYDTT; PSPB_HYDTT; RSBP_ ChEBI
Patent Database Links EP1520588; US2007249734 ChEBI
Reactome Database Links REACT_115834; REACT_116056 ChEBI
therap roborant MicroSource World Drugs

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
GRM4-3-E Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic Eukaryotes 1300 0.75 Binding ≤ 10μM
GRM6-1-E Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 2700 0.71 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
GRM4_HUMAN Q14833 Metabotropic Glutamate Receptor 4, Human 1000 0.76 Binding ≤ 1μM
GRM4_HUMAN Q14833 Metabotropic Glutamate Receptor 4, Human 1000 0.76 Binding ≤ 10μM
GRM4_RAT P31423 Metabotropic Glutamate Receptor 4, Rat 4000 0.69 Binding ≤ 10μM
GRM6_RAT P35349 Metabotropic Glutamate Receptor 6, Rat 2700 0.71 Binding ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description Species
Cysteine synthesis from O-phosphoserine
Serine biosynthesis

Reactome Annotations from Targets (via Uniprot)

Description Species
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.