| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 5th, 2005 | 12 | Yes |
Popular Name: swainsonine swainsonine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 214462-68-7 , 72741-87-8 , [72741-87-8]
214462-68-7; D06227; Tridolgosir hydrochloride (USAN)
72741-87-8; C10173; Swainsonine
Tridolgosir (INN); Tridolgosir HCl (INN
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -1.34 | -2.96 | -32.36 | 4 | 4 | 1 | 65 | 174.22 | 0 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | Apoptosis regulator BAX(Q07812)&Superoxide dismutase [Cu-Zn](P00441)&NAD-dependent deacetylase sirtuin-1(Q96EB6)&CREB-regulated transcription coactivator 3(Q6UUV7)&Glutathione reductase, mitochondrial(P00390) | Herbal Ingredients Targets |
| UniProt Database Links | MAN2_DROME; MNS1_ARATH; MNS2_ARATH; MNS3_ARATH | ChEBI |
| PUBCHEM_PATENT_ID | US5962467 | IBM Patent Data |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MA122-1-E | Mannosyl-oligosaccharide Alpha-1,2-mannosidase Isoform B (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.97 | Binding ≤ 10μM |
| MA2A1-1-E | Alpha-mannosidase 2A1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10000 | 0.58 | Binding ≤ 10μM |
| MA2B1-1-E | Lysosomal Alpha-mannosidase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 50 | 0.85 | Binding ≤ 10μM |
| MA2C1-1-E | Alpha-mannosidase 2C1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1750 | 0.67 | Binding ≤ 10μM |
| MA2C1-1-E | Alpha-mannosidase 2C1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10000 | 0.58 | Binding ≤ 10μM |
| Q9SEH8-1-E | Alpha-mannosidase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 400 | 0.75 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q9SEH8_SOYBN | Q9SEH8 | Alpha-mannosidase, Soybn | 400 | 0.75 | Binding ≤ 1μM |
| MA2B1_HUMAN | O00754 | Lysosomal Alpha-mannosidase, Human | 10 | 0.93 | Binding ≤ 1μM |
| MA122_DROME | P53625 | Mannosyl-oligosaccharide Alpha-1,2-mannosidase Isoform B, Drome | 3 | 0.99 | Binding ≤ 1μM |
| Q9SEH8_SOYBN | Q9SEH8 | Alpha-mannosidase, Soybn | 400 | 0.75 | Binding ≤ 10μM |
| MA2C1_RAT | P21139 | Alpha-mannosidase 2C1, Rat | 1750 | 0.67 | Binding ≤ 10μM |
| MA2B1_HUMAN | O00754 | Lysosomal Alpha-mannosidase, Human | 10 | 0.93 | Binding ≤ 10μM |
| MA2A1_RAT | P28494 | Mannosidase 2 Alpha 1, Rat | 10000 | 0.58 | Binding ≤ 10μM |
| MA122_DROME | P53625 | Mannosyl-oligosaccharide Alpha-1,2-mannosidase Isoform B, Drome | 3 | 0.99 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t |
