In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
January 30th, 2010 | 16 | Yes |
Popular Name: DNC010576 DNC010576
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.02 | 5.38 | -12.71 | 2 | 4 | 0 | 58 | 237.69 | 3 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GSK3B-4-E | Glycogen Synthase Kinase-3 Beta (cluster #4 Of 7), Eukaryotic | Eukaryotes | 354 | 0.56 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GSK3B_HUMAN | P49841 | Glycogen Synthase Kinase-3 Beta, Human | 354 | 0.56 | Binding ≤ 1μM |
GSK3B_HUMAN | P49841 | Glycogen Synthase Kinase-3 Beta, Human | 354 | 0.56 | Binding ≤ 10μM |
Description | Species |
---|---|
AKT phosphorylates targets in the cytosol | |
APC truncation mutants have impaired AXIN binding | |
AXIN missense mutants destabilize the destruction complex | |
Beta-catenin phosphorylation cascade | |
Constitutive PI3K/AKT Signaling in Cancer | |
CRMPs in Sema3A signaling | |
Degradation of beta-catenin by the destruction complex | |
disassembly of the destruction complex and recruitment of AXIN to the membrane | |
misspliced GSK3beta mutants stabilize beta-catenin | |
Regulation of HSF1-mediated heat shock response | |
S33 mutants of beta-catenin aren't phosphorylated | |
S37 mutants of beta-catenin aren't phosphorylated | |
S45 mutants of beta-catenin aren't phosphorylated | |
T41 mutants of beta-catenin aren't phosphorylated | |
truncations of AMER1 destabilize the destruction complex |