| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 5th, 2010 | 18 | Yes |
Popular Name: Imidazo[1,5-a]pyrido[3,2-e]pyrazine, 6,7-dimethyl-9-propyl- Imidazo[1,5-a]pyrido[3,2-e]pyraz…
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CAS Number: 959705-78-3
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.41 | 7.83 | -11.86 | 0 | 4 | 0 | 43 | 240.31 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE10-1-E | Phosphodiesterase 10A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 33 | 0.58 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE10_HUMAN | Q9Y233 | Phosphodiesterase 10A, Human | 32.5 | 0.58 | Binding ≤ 1μM |
| PDE10_HUMAN | Q9Y233 | Phosphodiesterase 10A, Human | 32.5 | 0.58 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| cGMP effects | |
| G alpha (s) signalling events |
No pre-computed analogs available. Try a structural similarity search.