| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 21st, 2005 | 44 | No |
Popular Name: Reserpine Reserpine
50-55-5; Apoplon (TN); D00197; Reserpine (JP16/USP/INN); Serpalan (TN)
50-55-5; Prestwick_147; Reserpine
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.01 | 11.7 | -45.84 | 2 | 11 | 1 | 119 | 609.696 | 10 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.13e-02 g/l | DrugBank-approved |
| biological_use | Antiadrenergic | IBScreen Bioactives IBScreen Bioactives |
| biological_use | Anticonvulsant agent | IBScreen Bioactives |
| Therapy | antihypertensive | SMDC MicroSource |
| biological_use | Antihypertensive agent acting by depleting stores of noradrenaline in sympathetic neurones | IBScreen Bioactives |
| Indications | antihypertensive, anxiolytic | KeyOrganics Bioactives |
| biological_use | Antineoplastic agent | IBScreen Bioactives |
| mechanism | Disruption of norepinephrine, serotonin, and dopamine presynaptic vesicles by the transporter VMAT | IBScreen Bioactives |
| UniProt Database Links | DOPO_HUMAN; DRRA_MYCTU; FLQE1_MYCTU; MFS55_MYCBO; MFS55_MYCTU | ChEBI |
| Patent Database Links | EP1553091; EP1634607; EP1717226; EP1815846; EP1829527; EP1829528; EP1860185; EP1884513; GB1489879; GB2264710; US2004132722; US2004142904; US2007207222; US2007264334; US2008280895; WO2005090305; WO2007098390; WO2007103687; WO2007110878; WO2007111958; WO200 | ChEBI |
| H phrase | H312: Harmful in contact with skin; H351: Suspected of causing cancer; H332: Harmful if inhaled; H302: Harmful if swallowed; H360D: May damage the unborn child | Acros Organics |
| Target | Interleukin-4(P05112)&Telomeric repeat-binding factor 1(P54274)&Fatty acid synthase(P49327)&Protein HIRA(P54198)&SERTA domain-containing protein 3(Q9UJW9)&Estrogen receptor(P03372)&Lipoprotein lipase(P06858)&Bcl-2 homologous antagonist/killer(Q16611)&3-hy | Herbal Ingredients Targets |
| P phrase | P280: Wear protective gloves/protective clothing/eye protection/face protection; P281: Use personal protective equipment as required; P201: Obtain special instructions before use; P308 + P313: IF exposed or concerned: Get medical advice/attention; P302 + | Acros Organics |
| biological_use | Possesses sedative tranquilliser props. | IBScreen Bioactives |
| R phrase | R61: May cause harm to the unborn child.; R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.; R40: Limited evidence of a carcinogenic effect. | Acros Organics |
| S phrase | S53: Avoid exposure - obtain special instructions before use.; S36/37: Wear suitable protective clothing and gloves.; S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). | Acros Organics |
| Hazard | T: Toxic | Acros Organics |
