| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 31st, 2005 | 15 | No |
Popular Name: (RS)-PPG (RS)-PPG
Find On: PubMed — Wikipedia — Google
CAS Numbers: 120667-15-4 , [120667-15-4]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.51 | 1.55 | -163.03 | 3 | 6 | -2 | 131 | 229.128 | 3 | ↓ |
| Mid Mid (pH 6-8) | -2.51 | 0.44 | -76.52 | 4 | 6 | -1 | 128 | 230.136 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM4-3-E | Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 4700 | 0.50 | Binding ≤ 10μM |
| GRM4-1-E | Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5200 | 0.49 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4700 | 0.50 | Functional ≤ 10μM |
| GRM8-2-E | Metabotropic Glutamate Receptor 8 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 210 | 0.62 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM4_HUMAN | Q14833 | Metabotropic Glutamate Receptor 4, Human | 4700 | 0.50 | Binding ≤ 10μM |
| GRM4_HUMAN | Q14833 | Metabotropic Glutamate Receptor 4, Human | 3200 | 0.51 | Functional ≤ 10μM |
| GRM4_RAT | P31423 | Metabotropic Glutamate Receptor 4, Rat | 5200 | 0.49 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 4700 | 0.50 | Functional ≤ 10μM |
| GRM6_RAT | P35349 | Metabotropic Glutamate Receptor 6, Rat | 4700 | 0.50 | Functional ≤ 10μM |
| GRM8_HUMAN | O00222 | Metabotropic Glutamate Receptor 8, Human | 210 | 0.62 | Functional ≤ 10μM |
| GRM8_RAT | P70579 | Metabotropic Glutamate Receptor 8, Rat | 210 | 0.62 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
