| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 31st, 2005 | 24 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.71 | 6.45 | -88.17 | 3 | 9 | -1 | 152 | 332.292 | 6 | ↓ |
| Hi High (pH 8-9.5) | -2.71 | 6.14 | -104.64 | 2 | 9 | -2 | 150 | 331.284 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1-1-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9250 | 0.29 | Functional ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9250 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 9250 | 0.29 | Functional ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 9250 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors |
