| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 6th, 2010 | 26 | Yes |
Popular Name: 1-[3-(4-tert-butylphenoxy)propyl]-4-(1-piperidyl)piperidine 1-[3-(4-tert-butylphenoxy)propyl…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.33 | 11.66 | -33.1 | 1 | 3 | 1 | 17 | 359.578 | 7 | ↓ |
| Lo Low (pH 4.5-6) | 5.33 | 13.9 | -103.98 | 2 | 3 | 2 | 18 | 360.586 | 7 | ↓ |
| Lo Low (pH 4.5-6) | 5.33 | 11.5 | -39.07 | 1 | 3 | 1 | 17 | 359.578 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HRH3-2-E | Histamine H3 Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 100 | 0.38 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HRH3_HUMAN | Q9Y5N1 | Histamine H3 Receptor, Human | 100 | 0.38 | Binding ≤ 1μM |
| HRH3_HUMAN | Q9Y5N1 | Histamine H3 Receptor, Human | 100 | 0.38 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (i) signalling events | |
| Histamine receptors |
