Physical Representations
|
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
|
Ref
Reference (pH 7)
|
2.97 |
6.19 |
-8.65 |
0 |
3 |
0 |
43 |
258.346 |
1 |
↓
|
Clustered Target Annotations
| Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
PK3CB-2-E |
PI3-kinase P110-beta Subunit (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
4163 |
0.42 |
Binding ≤ 10μM
|
ChEMBL Target Annotations
| Uniprot |
Swissprot |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
PK3CB_HUMAN |
P42338
|
PI3-kinase P110-beta Subunit, Human |
4163 |
0.42 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
| Description |
Species |
|
Constitutive PI3K/AKT Signaling in Cancer |
|
|
DAP12 signaling |
|
|
Downstream signal transduction |
|
|
Downstream TCR signaling |
|
|
GPVI-mediated activation cascade |
|
|
Interleukin receptor SHC signaling |
|
|
Interleukin-3, 5 and GM-CSF signaling |
|
|
Nephrin interactions |
|
|
PI3K Cascade |
|
|
PI3K/AKT activation |
|
|
PIP3 activates AKT signaling |
|
|
Regulation of signaling by CBL |
|
|
Role of LAT2/NTAL/LAB on calcium mobilization |
|
|
Role of phospholipids in phagocytosis |
|
|
Synthesis of PIPs at the plasma membrane |
|
|
Tie2 Signaling |
|
|
VEGFA-VEGFR2 Pathway |
|
No pre-computed analogs available. Try a structural similarity search.
