In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
April 14th, 2010 | 25 | Yes |
Popular Name: 3,5-dichloro-N-[[1-[(2R,3S)-2,3-dimethylpentyl]-4-piperidyl]methyl]benzamide 3,5-dichloro-N-[[1-[(2R,3S)-2,3-…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.59 | 11.73 | -44.09 | 2 | 3 | 1 | 34 | 386.387 | 7 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CAC1I-1-E | Voltage-gated T-type Calcium Channel Alpha-1I Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 38 | 0.42 | Binding ≤ 10μM |
KCNH2-5-E | HERG (cluster #5 Of 5), Eukaryotic | Eukaryotes | 883 | 0.34 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
KCNH2_HUMAN | Q12809 | HERG, Human | 883 | 0.34 | Binding ≤ 1μM |
CAC1I_HUMAN | Q9P0X4 | Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human | 38 | 0.42 | Binding ≤ 1μM |
KCNH2_HUMAN | Q12809 | HERG, Human | 883 | 0.34 | Binding ≤ 10μM |
CAC1I_HUMAN | Q9P0X4 | Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human | 38 | 0.42 | Binding ≤ 10μM |
Description | Species |
---|---|
NCAM1 interactions | |
Voltage gated Potassium channels |