| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 14th, 2010 | 36 | Yes |
Popular Name: benzyl benzyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.48 | 15.23 | -10.52 | 0 | 5 | 0 | 72 | 506.333 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| STAT3-1-E | Signal Transducer And Activator Of Transcription 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 130 | 0.27 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| STAT3_HUMAN | P40763 | Signal Transducer And Activator Of Transcription 3, Human | 130 | 0.27 | Binding ≤ 1μM |
| STAT3_HUMAN | P40763 | Signal Transducer And Activator Of Transcription 3, Human | 130 | 0.27 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Downstream signal transduction | |
| Growth hormone receptor signaling | |
| Interleukin-6 signaling | |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | |
| Senescence-Associated Secretory Phenotype (SASP) | |
| Signaling by FGFR1 fusion mutants | |
| Signaling by Leptin | |
| Signaling by SCF-KIT | |
| Signalling to STAT3 | |
| Transcriptional regulation of pluripotent stem cells |
