UCSF

Signal Transducer And Activator Of Transcription 3, Human (118 Compounds)

Swissprot:
STAT3_HUMAN
Stitch:
STAT3_HUMAN
UniProt:
P40763
ChEMBL:
CHEMBL4026
Reactome:
REACT_17025
REACT_111133
REACT_27307
REACT_200759
REACT_169168
REACT_121141
REACT_169118
REACT_111040
REACT_12049
REACT_200812
PDB:
STAT3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 118 2 1 1
Binding ≤ 1μM 70 2 1 1

Reactome Network (10)

Reactome ID Description Species
REACT_17025 Downstream signal transduction Homo sapiens
REACT_111133 Growth hormone receptor signaling Homo sapiens
REACT_27307 Interleukin-6 signaling Homo sapiens
REACT_200759 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Homo sapiens
REACT_169168 Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
REACT_121141 Signaling by FGFR1 fusion mutants Homo sapiens
REACT_169118 Signaling by Leptin Homo sapiens
REACT_111040 Signaling by SCF-KIT Homo sapiens
REACT_12049 Signalling to STAT3 Homo sapiens
REACT_200812 Transcriptional regulation of pluripotent stem cells Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1

Growth hormone receptor signaling

Uniprot Swissprot Chembl Description Number Shared
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1

Interleukin-6 signaling

Uniprot Swissprot Chembl Description Number Shared
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2

Senescence-Associated Secretory Phenotype (SASP)

Uniprot Swissprot Chembl Description Number Shared
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1

Signaling by FGFR1 fusion mutants

Uniprot Swissprot Chembl Description Number Shared
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1

Signaling by Leptin

Uniprot Swissprot Chembl Description Number Shared
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1

Signaling by SCF-KIT

Uniprot Swissprot Chembl Description Number Shared
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1

Signalling to STAT3

Uniprot Swissprot Chembl Description Number Shared
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
STAT3_MOUSE P42227 CHEMBL5402 Signal Transducer And Activator Of Transcription 3, Mouse 24 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
STAT6_HUMAN P42226 CHEMBL5401 Signal Transducer And Activator Of Transcription 6, Human 66 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
STAT3-1-E Signal Transducer And Activator Of Transcription 3 (cluster #1 Of 2), Eukaryotic 96 2 1 1
STAT3-2-E Signal Transducer And Activator Of Transcription 3 (cluster #2 Of 2), Eukaryotic 46 0 0 0
Uniprot Swissprot Chembl Description Number Shared
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 1
ITAL_HUMAN P20701 CHEMBL1803 Leukocyte Adhesion Glycoprotein LFA-1 Alpha, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
RB_HUMAN P06400 CHEMBL5288 Retinoblastoma-associated Protein, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
STA5A_HUMAN P42229 CHEMBL5403 Signal Transducer And Activator Of Transcription 5A, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1