UCSF

ZINC04097345

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
November 7th, 2005 31 Yes

Popular Name: Latanoprost Latanoprost

Find On: PubMed — Wikipedia — Google

CAS Numbers: 130209-82-4 , 913258-34-1

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.48 8.6 -10.92 3 5 0 87 432.601 14 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
PF2R-1-E Prostaglandin F2-alpha Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 92 0.32 Binding ≤ 10μM
PF2R-1-E Prostaglandin F2-alpha Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 34 0.34 Functional ≤ 10μM
Z80530-2-O Swiss-3T3 (Fibroblast Cells) (cluster #2 Of 2), Other Other 34 0.34 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
PF2R_BOVIN P37289 Prostanoid FP Receptor, Bovin 92 0.32 Binding ≤ 1μM
PF2R_BOVIN P37289 Prostanoid FP Receptor, Bovin 92 0.32 Binding ≤ 10μM
PF2R_HUMAN P43088 Prostanoid FP Receptor, Human 34.4 0.34 Functional ≤ 10μM
Z80530 Z80530 Swiss-3T3 (Fibroblast Cells) 34.4 0.34 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
G alpha (q) signalling events
Prostanoid ligand receptors

Analogs ( Draw Identity 99% 90% 80% 70% )