| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 5th, 2010 | 40 | No |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 9.66 | 9.38 | -73.72 | 0 | 6 | -2 | 96 | 606.61 | 10 | ↓ |
| Mid Mid (pH 6-8) | 9.66 | 9.1 | -38.78 | 1 | 6 | -1 | 94 | 607.618 | 10 | ↓ |
| Lo Low (pH 4.5-6) | 9.66 | 8.82 | -11.55 | 2 | 6 | 0 | 92 | 608.626 | 10 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PTN11-3-E | Protein-tyrosine Phosphatase 2C (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1800 | 0.20 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PTN11_HUMAN | Q06124 | Protein-tyrosine Phosphatase 2C, Human | 1800 | 0.20 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| Costimulation by the CD28 family | |
| CTLA4 inhibitory signaling | |
| Downstream signal transduction | |
| FRS2-mediated cascade | |
| GAB1 signalosome | |
| Interferon alpha/beta signaling | |
| Interleukin-3, 5 and GM-CSF signaling | |
| Interleukin-6 signaling | |
| Negative regulation of FGFR signaling | |
| Netrin mediated repulsion signals | |
| PD-1 signaling | |
| PECAM1 interactions | |
| PI-3K cascade | |
| PI3K Cascade | |
| PIP3 activates AKT signaling | |
| Platelet sensitization by LDL | |
| Prolactin receptor signaling | |
| Regulation of IFNA signaling | |
| Regulation of IFNG signaling | |
| Signal regulatory protein (SIRP) family interactions | |
| Signaling by Leptin | |
| Signaling by SCF-KIT | |
| Spry regulation of FGF signaling | |
| Tie2 Signaling |
