| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 9th, 2010 | 24 | Yes |
Popular Name: WAY 262611 dihydrochloride WAY 262611 dihydrochloride
Find On: PubMed — Wikipedia — Google
CAS Numbers: N.A. , [1123231-07-1]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.41 | 11.06 | -51.54 | 3 | 4 | 1 | 57 | 319.432 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DKK1-1-E | Dickkopf-related Protein 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 630 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DKK1_HUMAN | O94907 | Dickkopf-related Protein 1, Human | 630 | 0.36 | Binding ≤ 1μM |
| DKK1_HUMAN | O94907 | Dickkopf-related Protein 1, Human | 630 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling | |
| negative regulation of TCF-dependent signaling by WNT ligand antagonists | |
| TCF dependent signaling in response to WNT |
No pre-computed analogs available. Try a structural similarity search.