| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 6th, 2005 | 27 | Yes |
Popular Name: 10-Hydroxycamptothecin 10-Hydroxycamptothecin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 19685-09-7 , 64439-81-2 , 64439-81-2 / '19685-09-7 , 64439-81-2;19685-09-7 , [64439-81-2]
(+/-)-4-Ethyl-4,9-dihydroxy-1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
4-Ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.52 | -3.91 | -13.31 | 2 | 7 | 0 | 101 | 364.357 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | Inhibitor of DNA enzyme topoisomerase I | ZereneX Building Blocks IBScreen Bioactives |
| biological_source | Minor alkaloid from Camptotheca acuminata (Nyssaceae) | ZereneX Building Blocks |
| biological_use | Used in cancer chemotherapy | ZereneX Building Blocks |
