| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 23rd, 2010 | 31 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.00 | 13.13 | -112.55 | 4 | 5 | 2 | 59 | 426.58 | 8 | ↓ |
| Mid Mid (pH 6-8) | 5.00 | 11.78 | -40.25 | 3 | 5 | 1 | 54 | 425.572 | 8 | ↓ |
| Mid Mid (pH 6-8) | 5.00 | 10.74 | -51.59 | 3 | 5 | 1 | 58 | 425.572 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 5.00 | 13.08 | -153.25 | 5 | 5 | 3 | 60 | 427.588 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HRH4-1-E | Histamine H4 Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 557 | 0.28 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HRH4_HUMAN | Q9H3N8 | Histamine H4 Receptor, Human | 557 | 0.28 | Binding ≤ 1μM |
| HRH4_HUMAN | Q9H3N8 | Histamine H4 Receptor, Human | 557 | 0.28 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (i) signalling events | |
| Histamine receptors |
