| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 23rd, 2010 | 32 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.51 | 15.21 | -12.19 | 0 | 9 | 0 | 81 | 443.458 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MTOR-2-E | Serine/threonine-protein Kinase MTOR (cluster #2 Of 3), Eukaryotic | Eukaryotes | 60 | 0.32 | Binding ≤ 10μM |
| Z81170-1-O | LNCaP (Prostate Carcinoma) (cluster #1 Of 5), Other | Other | 180 | 0.30 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MTOR_RAT | P42346 | Serine/threonine-protein Kinase MTOR, Rat | 60 | 0.32 | Binding ≤ 1μM |
| MTOR_RAT | P42346 | Serine/threonine-protein Kinase MTOR, Rat | 60 | 0.32 | Binding ≤ 10μM |
| Z81170 | Z81170 | LNCaP (Prostate Carcinoma) | 180 | 0.30 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CD28 dependent PI3K/Akt signaling | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| HSF1-dependent transactivation | |
| mTOR signalling | |
| PIP3 activates AKT signaling | |
| Release of eIF4E | |
| S6K1-mediated signalling | |
| VEGFR2 mediated vascular permeability |
