| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 23rd, 2010 | 29 | Yes |
Popular Name: ethyl ethyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.21 | 4.72 | -53.15 | 2 | 9 | -1 | 128 | 398.443 | 10 | ↓ |
| Mid Mid (pH 6-8) | 3.75 | 6.59 | -14.17 | 3 | 9 | 0 | 125 | 399.451 | 10 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TLR7-1-E | Toll-like Receptor 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 188 | 0.32 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TLR7_HUMAN | Q9NYK1 | Toll-like Receptor 7, Human | 187.9 | 0.32 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| MyD88 dependent cascade initiated on endosome | |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | |
| Trafficking and processing of endosomal TLR |
