Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.26	8.93	-52.99	2	5	73	388.422	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.26	8.68	-13.23	1	5	71	387.414	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.26	8.98	-52.09	2	5	73	388.422	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.77	7.89	-15.96	1	5	75	387.414	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.77	8.01	-13.82	1	5	75	387.414	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.26	8.74	-12.86	1	5	71	387.414	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
MAPK2-1-E	MAP Kinase-activated Protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5800	0.25	Binding ≤ 10μM
Z80548-1-O	THP-1 (Acute Monocytic Leukemia Cells) (cluster #1 Of 5), Other	Other	2200	0.27	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
MAPK2_HUMAN	P49137	MAP Kinase-activated Protein Kinase 2, Human	5800	0.25	Binding ≤ 10μM
Z80548	Z80548	THP-1 (Acute Monocytic Leukemia Cells)	2200	0.27	Functional ≤ 10μM

Description	Species
activated TAK1 mediates p38 MAPK activation	Homo sapiens (MAPK2_HUMAN)
Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Homo sapiens (MAPK2_HUMAN)
CREB phosphorylation	Homo sapiens (MAPK2_HUMAN)
Oxidative Stress Induced Senescence	Homo sapiens (MAPK2_HUMAN)
p38MAPK events	Homo sapiens (MAPK2_HUMAN)
Regulation of HSF1-mediated heat shock response	Homo sapiens (MAPK2_HUMAN)
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Homo sapiens (MAPK2_HUMAN)
Tristetraprolin (TTP) destabilizes mRNA	Homo sapiens (MAPK2_HUMAN)
VEGFA-VEGFR2 Pathway	Homo sapiens (MAPK2_HUMAN)