| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 11th, 2010 | 38 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.14 | 13.85 | -46.8 | 3 | 8 | 1 | 84 | 541.116 | 9 | ↓ |
| Mid Mid (pH 6-8) | 5.14 | 14.14 | -92.89 | 4 | 8 | 2 | 85 | 542.124 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CCR4-1-E | C-C Chemokine Receptor Type 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 61 | 0.27 | Binding ≤ 10μM |
| CCR4-1-E | C-C Chemokine Receptor Type 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 390 | 0.24 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CCR4_HUMAN | P51679 | C-C Chemokine Receptor Type 4, Human | 61 | 0.27 | Binding ≤ 1μM |
| CCR4_HUMAN | P51679 | C-C Chemokine Receptor Type 4, Human | 61 | 0.27 | Binding ≤ 10μM |
| CCR4_MOUSE | P51680 | C-C Chemokine Receptor Type 4, Mouse | 390 | 0.24 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Chemokine receptors bind chemokines | |
| G alpha (i) signalling events |
