| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 15th, 2006 | 21 | Yes |
Popular Name: 6-methoxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic 6-methoxy-1,4a-dimethyl-2,3,4,9,…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.21 | 1.91 | -52.28 | 0 | 3 | -1 | 49 | 287.379 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA-2-E | DNA Polymerase Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 4000 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 4000 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the pre-replicative complex | |
| DNA replication initiation | |
| E2F mediated regulation of DNA replication | |
| G1/S-Specific Transcription | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Leading Strand Synthesis | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of the Flap Intermediate | |
| Telomere C-strand synthesis initiation |
