| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 24th, 2004 | 17 | Yes |
Popular Name: (1S)-6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (1S)-6-methyl-2,3,4,9-tetrahydro…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.28 | 4.46 | -11.31 | 3 | 3 | 0 | 59 | 228.295 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SIRT1-1-E | NAD-dependent Deacetylase Sirtuin 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2500 | 0.46 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SIRT1_HUMAN | Q96EB6 | NAD-dependent Deacetylase Sirtuin 1, Human | 205 | 0.55 | Binding ≤ 1μM |
| SIRT1_HUMAN | Q96EB6 | NAD-dependent Deacetylase Sirtuin 1, Human | 205 | 0.55 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Regulation of HSF1-mediated heat shock response | |
| SIRT1 negatively regulates rRNA Expression |
