Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.53	8.9	-63.91	7	8	1	125	394.503	5	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	2.53	9.29	-113.62	8	8	2	126	395.511	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.40	Binding ≤ 10μM
ZAP70-1-E	Tyrosine-protein Kinase ZAP-70 (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.31	Binding ≤ 10μM
Z100081-1-O	PBMC (Peripheral Blood Mononuclear Cells) (cluster #1 Of 4), Other	Other	200	0.32	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
KSYK_HUMAN	P43405	Tyrosine-protein Kinase SYK, Human	6	0.40	Binding ≤ 1μM
ZAP70_HUMAN	P43403	Tyrosine-protein Kinase ZAP-70, Human	480	0.31	Binding ≤ 1μM
KSYK_HUMAN	P43405	Tyrosine-protein Kinase SYK, Human	6	0.40	Binding ≤ 10μM
ZAP70_HUMAN	P43403	Tyrosine-protein Kinase ZAP-70, Human	480	0.31	Binding ≤ 10μM
Z100081	Z100081	PBMC (Peripheral Blood Mononuclear Cells)	200	0.32	Functional ≤ 10μM

Description	Species
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge	Homo sapiens (KSYK_HUMAN)
DAP12 signaling	Homo sapiens (KSYK_HUMAN)
Fc epsilon receptor (FCERI) signaling	Homo sapiens (KSYK_HUMAN)
FCERI mediated Ca+2 mobilization	Homo sapiens (KSYK_HUMAN)
FCERI mediated MAPK activation	Homo sapiens (KSYK_HUMAN)
FCGR activation	Homo sapiens (KSYK_HUMAN)
Generation of second messenger molecules	Homo sapiens (ZAP70_HUMAN)
GPVI-mediated activation cascade	Homo sapiens (KSYK_HUMAN)
Integrin alphaIIb beta3 signaling	Homo sapiens (KSYK_HUMAN)
Interleukin-2 signaling	Homo sapiens (KSYK_HUMAN)
Regulation of actin dynamics for phagocytic cup formation	Homo sapiens (KSYK_HUMAN)
Regulation of signaling by CBL	Homo sapiens (KSYK_HUMAN)
Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens (KSYK_HUMAN)
Role of phospholipids in phagocytosis	Homo sapiens (KSYK_HUMAN)
Translocation of ZAP-70 to Immunological synapse	Homo sapiens (ZAP70_HUMAN)