| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 19 | Yes |
Popular Name: Sulfamethazine Sulfamethazine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1981-58-4 , 35762-76-6 , 359-07-9 , 57-68-1 , [1981-58-4] , [57-68-1]
(p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
(p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin [German]
1981-58-4; Prestwick_1014; Sulfamethazine sodium salt
2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
2-Sulfanilamido-4,6-dimethylpyrimidine
4,6-Dimethyl-2-sulfanilamidopyrimidine
4-Amino-N- [4,6-dimethyl-2-pyrimidinyl]- benzenesulfonamide
4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide
4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
5-25-10-00250 (Beilstein Handbook Reference)
57-68-1; C19530; Sulfamethazine
57-68-1; D02436; Sulfadimidine (INN); Sulfamethazine (USP); Sulfamezathine (TN)
6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin [German]
benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-
INN); Sulfamethazine (USP); Sulfamethazine (Trisulfapyrimidines) (FDA)
N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
N(sup 1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(sup 1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
n(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide
N(Sup1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
N(Sup1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
sulfadimidina; sulfadimidine; sulfadimidinum
Sulfamethazine (Trisulfapyrimidines) (FDA); Sulfadimidine (BAN
Sulfanilamide, N(1)-(4,6-dimethyl-2-pyrimidinyl)-
Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-
Sulfanilamide, N(sup1)-(2,6-dimethyl-4-pyrimidinyl)-
Sulfanilamide, N(sup1)-(4,6-dimethyl-2-pyrimidinyl)-
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.84 | 3.5 | -13.79 | 3 | 6 | 0 | 98 | 278.337 | 3 | ↓ |
| Mid Mid (pH 6-8) | 0.84 | 3.2 | -57.09 | 2 | 6 | -1 | 100 | 277.329 | 3 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | . | ZereneX Building Blocks |
| Mp [°C] | 197 - 200 | Acros Organics |
| MP | 198 - 201 | Enamine Building Blocks |
| Melting_Point | 198-201? | Alfa-Aesar |
| Melting_Point | 198-201° | Alfa-Aesar |
| MP | 198...201 | Enamine Building Blocks |
| MP | 199 | TCI |
| ALOGPS_SOLUBILITY | 2.30e-01 g/l | DrugBank-approved |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Therapy | antibacterial | SMDC Iconix |
| Target | Antifection | Selleck Chemicals |
| biological_use | Antiseptic | IBScreen Bioactives IBScreen Bioactives |
| mechanism | Dihydrofolate-reductase inhibitor | IBScreen Bioactives |
| mechanism | Dihydrofolate-synthesis inhibitor | IBScreen Bioactives |
| mechanism | Folate-antagonist | IBScreen Bioactives |
| biological_use | Low acute toxicity | IBScreen Bioactives |
| Target | Others | Selleck Chemicals |
| S phrase | S24/25: Avoid contact with skin and eyes. | Acros Organics |
| UniProt Database Links | SMZ_ARATH | ChEBI |
| mechanism | Subsequent reduction in the level of folic acid reduced the production of nucleic acids in sensitive bacteria. | IBScreen Bioactives |
| mechanism | Sulfonamides, being structural analogues of para-aminobenzoic acid (PABA), competitively inhibit the incorporation of PABA into dihydropteric acid, the precursor of folic acid. | IBScreen Bioactives |
| biological_use | Widely-used, short acting sulfonamide, used in treatment of systemic and urinary tract infections | IBScreen Bioactives |
