| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 12th, 2006 | 20 | No |
Popular Name: DNC014569 DNC014569
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.46 | 0.96 | -5.24 | 0 | 4 | 0 | 44 | 266.3 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CATG-2-E | Cathepsin G (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2 | 0.61 | Binding ≤ 10μM |
| CMA1-1-E | Mast Cell Protease 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 140 | 0.48 | Binding ≤ 10μM |
| CTRC-4-E | Chymotrypsin C (cluster #4 Of 4), Eukaryotic | Eukaryotes | 2 | 0.61 | Binding ≤ 10μM |
| ELNE-3-E | Neutrophil Elastase (cluster #3 Of 3), Eukaryotic | Eukaryotes | 230 | 0.46 | Binding ≤ 10μM |
| THRB-5-E | Prothrombin (cluster #5 Of 8), Eukaryotic | Eukaryotes | 2300 | 0.39 | Binding ≤ 10μM |
| TRY1-1-E | Trypsin I (cluster #1 Of 5), Eukaryotic | Eukaryotes | 200 | 0.47 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CATG_HUMAN | P08311 | Cathepsin G, Human | 2.3 | 0.60 | Binding ≤ 1μM |
| CMA1_HUMAN | P23946 | Chymase, Human | 140 | 0.48 | Binding ≤ 1μM |
| CTRC_HUMAN | Q99895 | Chymotrypsin C, Human | 2.4 | 0.60 | Binding ≤ 1μM |
| ELNE_HUMAN | P08246 | Leukocyte Elastase, Human | 230 | 0.46 | Binding ≤ 1μM |
| TRY1_BOVIN | P00760 | Trypsin I, Bovin | 200 | 0.47 | Binding ≤ 1μM |
| CATG_HUMAN | P08311 | Cathepsin G, Human | 2.3 | 0.60 | Binding ≤ 10μM |
| CMA1_HUMAN | P23946 | Chymase, Human | 140 | 0.48 | Binding ≤ 10μM |
| CTRC_HUMAN | Q99895 | Chymotrypsin C, Human | 2.4 | 0.60 | Binding ≤ 10μM |
| ELNE_HUMAN | P08246 | Leukocyte Elastase, Human | 230 | 0.46 | Binding ≤ 10μM |
| THRB_HUMAN | P00734 | Thrombin, Human | 2300 | 0.39 | Binding ≤ 10μM |
| TRY1_BOVIN | P00760 | Trypsin I, Bovin | 200 | 0.47 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Cell surface interactions at the vascular wall | |
| Collagen degradation | |
| Common Pathway | |
| Degradation of the extracellular matrix | |
| G alpha (q) signalling events | |
| Gamma-carboxylation of protein precursors | |
| Intrinsic Pathway | |
| Metabolism of Angiotensinogen to Angiotensins | |
| Peptide ligand-binding receptors | |
| Platelet Aggregation (Plug Formation) | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Signaling by SCF-KIT | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
No pre-computed analogs available. Try a structural similarity search.