UCSF

ZINC05764407

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
February 12th, 2006 20 No

Popular Name: Norandrostenedione-19 Norandrostenedione-19

Find On: PubMed — Wikipedia — Google

CAS Number: 734-32-7

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.82 9.03 -10.73 0 2 0 34 272.388 0 ↓

Vendor Notes

Note Type Comments Provided By
biological_source Semisynth. steroid prod. from estr-4-ene-17a-ol-3-one by incubating with Corynebacterium simplex ZereneX Building Blocks
mechanism 19-Norandrostenedione is not metabolized to testosterone. IBScreen Bioactives
mechanism 19-Norandrostenedione may be metabolized to 19-nortestosterone in both men and women. 19-Norandrostenedione, IBScreen Bioactives
biological_use 19-Norandrostenedione refers to two steroid isomers that are marketed as dietary supplements and mainly used by body builders IBScreen Bioactives
Purity 95% APIChem
mechanism also known as nandrolone, is the basic substance of some very popular injectable anabolic steroids. IBScreen Bioactives
biological_use Androgen IBScreen Bioactives IBScreen Bioactives
mechanism Whether increases in 19-nortestosterone levels that may be produced by taking oral 19-norandrostenedione IBScreen Bioactives
mechanism would be sustained long enough to show increase in nitrogen retention and muscle strength and mass is unknown IBScreen Bioactives

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
CP19A-2-E Cytochrome P450 19A1 (cluster #2 Of 3), Eukaryotic Eukaryotes 140 0.48 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
CP19A_HUMAN P11511 Cytochrome P450 19A1, Human 140 0.48 Binding ≤ 1μM
CP19A_HUMAN P11511 Cytochrome P450 19A1, Human 1200 0.41 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Endogenous sterols
Estrogen biosynthesis

Analogs ( Draw Identity 99% 90% 80% 70% )