| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 18 | Yes |
Popular Name: 6-Hydroxyflavone 6-Hydroxyflavone
Find On: PubMed — Wikipedia — Google
CAS Number: 6665-83-4
6-hydroxy-2-phenyl-4-benzopyrone; 6-hydroxyflavone; 6-monohydroxyflavone; CPD-8138
6-Hydroxy-2-phenyl-4-benzopyrone; 6-Hydroxyflavone; 6665-83-4; C14137
6-Hydroxy-2-phenyl-4-benzopyrone; 6-Hydroxyflavone; EINECS 229-704-8; LS-195382; NSC 26744
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.23 | 5.43 | -11.14 | 1 | 3 | 0 | 50 | 238.242 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| M.P. | 230-232 C | Indofine |
| MP | 231-232o C | Indofine |
| Melting_Point | 234-236? | Alfa-Aesar |
| Melting_Point | 234-236° | Alfa-Aesar |
| SOLUBILITY | Clear solution in Methanol | Indofine |
| APPEARANCE | Pale Yellow crystals | Indofine |
| SOLUBILITY | Solube in Methanol | Indofine |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CALM-1-E | Calmodulin (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5170 | 0.41 | Binding ≤ 10μM |
| Z104301-4-O | GABA-A Receptor; Anion Channel (cluster #4 Of 8), Other | Other | 400 | 0.50 | Binding ≤ 10μM |
| Z50425-11-O | Plasmodium Falciparum (cluster #11 Of 22), Other | Other | 5300 | 0.41 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 400 | 0.50 | Binding ≤ 1μM |
| CALM_HUMAN | P62158 | Calmodulin, Human | 5170 | 0.41 | Binding ≤ 10μM |
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 400 | 0.50 | Binding ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 5300 | 0.41 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Ca-permeable Kainate Receptor | |
| Activation of CaMK IV | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| Ca2+ pathway | |
| Calmodulin induced events | |
| CaM pathway | |
| Cam-PDE 1 activation | |
| CaMK IV-mediated phosphorylation of CREB | |
| CREB phosphorylation through the activation of CaMKII | |
| CREB phosphorylation through the activation of CaMKK | |
| DARPP-32 events | |
| eNOS activation | |
| FCERI mediated Ca+2 mobilization | |
| Glycogen breakdown (glycogenolysis) | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| Platelet degranulation | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Smooth Muscle Contraction | |
| Synthesis of IP3 and IP4 in the cytosol | |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | |
| Transcriptional activation of mitochondrial biogenesis | |
| Translocation of GLUT4 to the plasma membrane | |
| VEGFR2 mediated cell proliferation | |
| VEGFR2 mediated vascular permeability |
