| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 17th, 2006 | 23 | No |
Popular Name: 2-ethoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 2-ethoxy-13-methyl-6,7,8,9,11,12…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.62 | -2.32 | -6.76 | 2 | 3 | 0 | 49 | 316.441 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 910 | 0.37 | Binding ≤ 10μM |
| Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 660 | 0.38 | Functional ≤ 10μM |
| Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1300 | 0.36 | Functional ≤ 10μM |
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 660 | 0.38 | Functional ≤ 10μM |
| Z81057-2-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #2 Of 4), Other | Other | 120 | 0.42 | Functional ≤ 10μM |
| Z81252-4-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #4 Of 11), Other | Other | 550 | 0.38 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 910 | 0.37 | Binding ≤ 1μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 910 | 0.37 | Binding ≤ 10μM |
| Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 120 | 0.42 | Functional ≤ 10μM |
| Z81252 | Z81252 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 550 | 0.38 | Functional ≤ 10μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1300 | 0.36 | Functional ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1300 | 0.36 | Functional ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1300 | 0.36 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
