Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.09	13.44	-81.25	3	4	2	34	414.528	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	6.09	10.64	-8.64	1	4	0	31	412.512	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	6.09	11.08	-34.43	2	4	1	33	413.52	4	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
MAPK2-1-E	MAP Kinase-activated Protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	700	0.28	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
MAPK2_HUMAN	P49137	MAP Kinase-activated Protein Kinase 2, Human	700	0.28	Binding ≤ 1μM
MAPK2_HUMAN	P49137	MAP Kinase-activated Protein Kinase 2, Human	700	0.28	Binding ≤ 10μM

Description	Species
activated TAK1 mediates p38 MAPK activation	Homo sapiens (MAPK2_HUMAN)
Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Homo sapiens (MAPK2_HUMAN)
CREB phosphorylation	Homo sapiens (MAPK2_HUMAN)
Oxidative Stress Induced Senescence	Homo sapiens (MAPK2_HUMAN)
p38MAPK events	Homo sapiens (MAPK2_HUMAN)
Regulation of HSF1-mediated heat shock response	Homo sapiens (MAPK2_HUMAN)
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Homo sapiens (MAPK2_HUMAN)
Tristetraprolin (TTP) destabilizes mRNA	Homo sapiens (MAPK2_HUMAN)
VEGFA-VEGFR2 Pathway	Homo sapiens (MAPK2_HUMAN)