| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 27th, 2005 | 34 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.51 | 1.8 | -12.67 | 1 | 5 | 0 | 54 | 473.935 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| OXYR-1-E | Oxytocin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 519 | 0.26 | Binding ≤ 10μM |
| V1AR-1-E | Vasopressin V1a Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6000 | 0.22 | Binding ≤ 10μM |
| V2R-1-E | Vasopressin V2 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.36 | Binding ≤ 10μM |
| V2R-1-E | Vasopressin V2 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 91 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| OXYR_HUMAN | P30559 | Oxytocin Receptor, Human | 519 | 0.26 | Binding ≤ 1μM |
| V1AR_HUMAN | P37288 | Vasopressin V1a Receptor, Human | 124 | 0.28 | Binding ≤ 1μM |
| V1AR_RAT | P30560 | Vasopressin V1a Receptor, Rat | 340 | 0.27 | Binding ≤ 1μM |
| V2R_HUMAN | P30518 | Vasopressin V2 Receptor, Human | 1 | 0.37 | Binding ≤ 1μM |
| V2R_RAT | Q00788 | Vasopressin V2 Receptor, Rat | 0.5 | 0.38 | Binding ≤ 1μM |
| OXYR_HUMAN | P30559 | Oxytocin Receptor, Human | 519 | 0.26 | Binding ≤ 10μM |
| V1AR_HUMAN | P37288 | Vasopressin V1a Receptor, Human | 124 | 0.28 | Binding ≤ 10μM |
| V1AR_RAT | P30560 | Vasopressin V1a Receptor, Rat | 340 | 0.27 | Binding ≤ 10μM |
| V2R_RAT | Q00788 | Vasopressin V2 Receptor, Rat | 0.5 | 0.38 | Binding ≤ 10μM |
| V2R_HUMAN | P30518 | Vasopressin V2 Receptor, Human | 1 | 0.37 | Binding ≤ 10μM |
| V2R_HUMAN | P30518 | Vasopressin V2 Receptor, Human | 5 | 0.34 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (q) signalling events | |
| G alpha (s) signalling events | |
| Vasopressin regulates renal water homeostasis via Aquaporins | |
| Vasopressin-like receptors |
