UCSF

ZINC00629244

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Substance Information

In ZINC since Heavy atoms Benign functionality
July 25th, 2004 28 No

Popular Name: (-)-Bicuculline methiodide (-)-Bicuculline methiodide

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CAS Numbers: 40709-69-1 , 55950-07-7 , [55950-07-7]

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.10 9.04 -65.76 0 7 1 63 382.392 1 ↓

Vendor Notes

Note Type Comments Provided By
therap GABAa antagonist MicroSource Spectrum

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KCNN3-2-E Small Conductance Calcium-activated Potassium Channel Protein 3 (cluster #2 Of 2), Eukaryotic Eukaryotes 7000 0.26 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KCNN3_RAT P70605 Small Conductance Calcium-activated Potassium Channel Protein 3, Rat 4400 0.27 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Ca2+ activated K+ channels

Analogs ( Draw Identity 99% 90% 80% 70% )