Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.91	3.41	-12.12	1	5	0	58	231.255	1	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.37	1.34	-46.43	0	5	-1	61	230.247	1	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
PK3CB-1-E	PI3-kinase P110-beta Subunit (cluster #1 Of 2), Eukaryotic	Eukaryotes	5800	0.43	Binding ≤ 10μM
PK3CD-1-E	PI3-kinase P110-delta Subunit (cluster #1 Of 2), Eukaryotic	Eukaryotes	6400	0.43	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
PK3CB_HUMAN	P42338	PI3-kinase P110-beta Subunit, Human	5800	0.43	Binding ≤ 10μM
PK3CD_HUMAN	O00329	PI3-kinase P110-delta Subunit, Human	6400	0.43	Binding ≤ 10μM

Description	Species
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge	Homo sapiens (PK3CD_HUMAN)
Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens (PK3CD_HUMAN)
DAP12 signaling	Homo sapiens (PK3CB_HUMAN)
Downstream signal transduction	Homo sapiens (PK3CB_HUMAN)
Downstream TCR signaling	Homo sapiens (PK3CB_HUMAN)
GPVI-mediated activation cascade	Homo sapiens (PK3CB_HUMAN)
Interleukin receptor SHC signaling	Homo sapiens (PK3CD_HUMAN)
Interleukin-3, 5 and GM-CSF signaling	Homo sapiens (PK3CD_HUMAN)
Nephrin interactions	Homo sapiens (PK3CB_HUMAN)
PI3K Cascade	Homo sapiens (PK3CB_HUMAN)
PI3K/AKT activation	Homo sapiens (PK3CB_HUMAN)
PIP3 activates AKT signaling	Homo sapiens (PK3CD_HUMAN)
Regulation of signaling by CBL	Homo sapiens (PK3CD_HUMAN)
Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens (PK3CB_HUMAN)
Role of phospholipids in phagocytosis	Homo sapiens (PK3CB_HUMAN)
Synthesis of PIPs at the plasma membrane	Homo sapiens (PK3CD_HUMAN)
Tie2 Signaling	Homo sapiens (PK3CB_HUMAN)
VEGFA-VEGFR2 Pathway	Homo sapiens (PK3CB_HUMAN)