| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 23rd, 2005 | 21 | No |
Popular Name: 4-[(5-oxo-2-phenyl-oxazol-4-ylidene)methyl]benzonitrile 4-[(5-oxo-2-phenyl-oxazol-4-ylid…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.07 | 2 | -10.96 | 0 | 4 | 0 | 66 | 274.279 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLCG2-2-E | Phospholipase C-gamma-2 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.38 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLCG2_HUMAN | P16885 | Phospholipase C-gamma-2, Human | 2000 | 0.38 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| DAP12 signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| GPVI-mediated activation cascade | |
| Role of phospholipids in phagocytosis | |
| Synthesis of IP3 and IP4 in the cytosol | |
| Toll Like Receptor 4 (TLR4) Cascade |
