| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 27th, 2006 | 24 | Yes |
Popular Name: JNJ-16259685 JNJ-16259685
Find On: PubMed — Wikipedia — Google
CAS Number: 409345-29-5
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.61 | 7.01 | -12.95 | 0 | 4 | 0 | 48 | 325.408 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1-1-E | Metabotropic Glutamate Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 106 | 0.41 | Binding ≤ 10μM |
| GRM1-1-E | Metabotropic Glutamate Receptor 1 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 1 | 0.53 | Functional ≤ 10μM |
| Z50587-5-O | Homo Sapiens (cluster #5 Of 9), Other | Other | 77 | 0.41 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 0.34 | 0.55 | Binding ≤ 1μM |
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 3 | 0.50 | Binding ≤ 1μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 0.34 | 0.55 | Binding ≤ 10μM |
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 3 | 0.50 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 73 | 0.42 | Functional ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 1.21 | 0.52 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (q) signalling events |
No pre-computed analogs available. Try a structural similarity search.