In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
July 14th, 2006 | 18 | No |
1,4-bis[2-(diaminomethylene)carbohydrazonoyl]benzene
N''-{4-[2-(diaminomethylene)carbohydrazonoyl]benzylidene}carbonohydrazonic diamide
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | -0.98 | 4.23 | -71.27 | 10 | 8 | 2 | 157 | 248.294 | 4 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FURIN-1-E | Furin (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1470 | 0.45 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FURIN_HUMAN | P09958 | Furin, Human | 1470 | 0.45 | Binding ≤ 10μM |
Description | Species |
---|---|
Activation of Matrix Metalloproteinases | |
Collagen degradation | |
Elastic fibre formation | |
NGF processing | |
Pre-NOTCH Processing in Golgi | |
Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
Signaling by NODAL | |
Signaling by PDGF | |
Synthesis and processing of ENV and VPU | |
TGF-beta receptor signaling activates SMADs | |
Uptake and function of anthrax toxins |