UCSF

Furin, Human (76 Compounds)

Swissprot:
FURIN_HUMAN
Stitch:
FURIN_HUMAN
UniProt:
P09958
ChEMBL:
CHEMBL2611
Reactome:
REACT_118682
REACT_150401
REACT_150366
REACT_11062
REACT_118798
REACT_733
REACT_111057
REACT_16888
REACT_163660
REACT_120850
REACT_228255
PDB:
FURIN

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 76 1 0 0
Binding ≤ 1μM 49 0 0 0

Reactome Network (11)

Reactome ID Description Species
REACT_118682 Activation of Matrix Metalloproteinases Homo sapiens
REACT_150401 Collagen degradation Homo sapiens
REACT_150366 Elastic fibre formation Homo sapiens
REACT_11062 NGF processing Homo sapiens
REACT_118798 Pre-NOTCH Processing in Golgi Homo sapiens
REACT_733 Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
REACT_111057 Signaling by NODAL Homo sapiens
REACT_16888 Signaling by PDGF Homo sapiens
REACT_163660 Synthesis and processing of ENV and VPU Homo sapiens
REACT_120850 TGF-beta receptor signaling activates SMADs Homo sapiens
REACT_228255 Uptake and function of anthrax toxins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1

NGF processing

Uniprot Swissprot Chembl Description Number Shared
PCSK5_HUMAN Q92824 CHEMBL2826 Subtilisin/kexin Type 5, Human 5
PCSK6_HUMAN P29122 CHEMBL2951 Subtilisin/kexin Type 6, Human 5

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Uniprot Swissprot Chembl Description Number Shared
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1

Signaling by NODAL

Uniprot Swissprot Chembl Description Number Shared
PCSK6_HUMAN P29122 CHEMBL2951 Subtilisin/kexin Type 6, Human 5

Signaling by PDGF

Uniprot Swissprot Chembl Description Number Shared
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
FURIN-1-E Furin (cluster #1 Of 2), Eukaryotic 16 1 0 0
FURIN-2-E Furin (cluster #2 Of 2), Eukaryotic 60 0 0 0
Uniprot Swissprot Chembl Description Number Shared
NEC1_HUMAN P29120 CHEMBL3182 Prohormone Convertase 1, Human 5
PCSK5_HUMAN Q92824 CHEMBL2826 Subtilisin/kexin Type 5, Human 5
PCSK6_HUMAN P29122 CHEMBL2951 Subtilisin/kexin Type 6, Human 5
NEC2_HUMAN P16519 CHEMBL2433 Prohormone Convertase 2, Human 3
PCSK7_HUMAN Q16549 CHEMBL2232 Subtilisin/kexin Type 7, Human 3
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1

Most Common Rings