Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.73	11.11	-13.04	1	6	0	73	352.781	3	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.73	11.59	-46.83	2	6	1	74	353.789	3	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE4A-3-E	Phosphodiesterase 4A (cluster #3 Of 3), Eukaryotic	Eukaryotes	6550	0.29	Binding ≤ 10μM
PDE4B-2-E	Phosphodiesterase 4B (cluster #2 Of 2), Eukaryotic	Eukaryotes	6550	0.29	Binding ≤ 10μM
PDE4C-2-E	Phosphodiesterase 4C (cluster #2 Of 2), Eukaryotic	Eukaryotes	6550	0.29	Binding ≤ 10μM
PDE4D-2-E	Phosphodiesterase 4D (cluster #2 Of 2), Eukaryotic	Eukaryotes	6550	0.29	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE4A_HUMAN	P27815	Phosphodiesterase 4A, Human	42	0.41	Binding ≤ 1μM
PDE4B_HUMAN	Q07343	Phosphodiesterase 4B, Human	42	0.41	Binding ≤ 1μM
PDE4C_HUMAN	Q08493	Phosphodiesterase 4C, Human	42	0.41	Binding ≤ 1μM
PDE4D_HUMAN	Q08499	Phosphodiesterase 4D, Human	42	0.41	Binding ≤ 1μM
PDE4A_HUMAN	P27815	Phosphodiesterase 4A, Human	42	0.41	Binding ≤ 10μM
PDE4B_HUMAN	Q07343	Phosphodiesterase 4B, Human	42	0.41	Binding ≤ 10μM
PDE4C_HUMAN	Q08493	Phosphodiesterase 4C, Human	42	0.41	Binding ≤ 10μM
PDE4D_HUMAN	Q08499	Phosphodiesterase 4D, Human	42	0.41	Binding ≤ 10μM