| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 20th, 2013 | 59 | No |
Popular Name: Vincaleukoblastine Vincaleukoblastine
143-67-9; D01068; Exal (TN); Velban (TN); Vinblastine sulfate (JP16/USP)
865-21-4; D08675; Vinblastina (TN); Vinblastine (INN)
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.56 | 13.39 | -42.22 | 4 | 13 | 1 | 155 | 811.997 | 10 | ↓ |
| Mid Mid (pH 6-8) | 5.56 | 16.11 | -120.28 | 5 | 13 | 2 | 157 | 813.005 | 10 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.69e-02 g/l | DrugBank-approved |
| UniProt Database Links | 10HGO_CATRO; DAT_CATRO; H10_HUMAN; MDR1_LEIEN; Y1866_STAAM | ChEBI |
| biological_use | Antineoplastic agent | IBScreen Bioactives IBScreen Bioactives |
| mechanism | Binds tubulin, inhibiting the assembly of microtubules | IBScreen Bioactives |
| mechanism | Binds tubulin, inhibiting the assembly of microtubules | IBScreen Bioactives |
| biological_use | Used widely in the treatment of Hodgkin's disease and other lymphomas | IBScreen Bioactives |
| Patent Database Links | WO2007098183 | ChEBI |
No pre-computed analogs available. Try a structural similarity search.